Functional modeling of the shift in cellular calcium dynamics at the onset of synchronization in smooth muscle cells.
Bull Math Biol
; 73(10): 2507-25, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21387191
ABSTRACT
In the present paper we address the nature of synchronization properties found in populations of mesenteric artery smooth muscle cells. We present a minimal model of the onset of synchronization in the individual smooth muscle cell that is manifested as a transition from calcium waves to whole-cell calcium oscillations. We discuss how different types of ion currents may influence both amplitude and frequency in the regime of whole-cell oscillations. The model may also explain the occurrence of mixed-mode oscillations and chaotic oscillations frequently observed in the experimental system.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article