Recognition of thymine in DNA bulges by a Zn(II) macrocyclic complex.
Chem Commun (Camb)
; 47(30): 8566-8, 2011 Aug 14.
Article
em En
| MEDLINE
| ID: mdl-21706105
ABSTRACT
A Zn(II) macrocyclic complex with appended quinoline is a bifunctional recognition agent that uses both the Zn(II) center and the pendent aromatic group to bind to thymine in bulges with good selectivity over DNA containing G, C or A bulges. Spectroscopic studies show that the stem containing the bulge stays largely intact in a DNA hairpin with the Zn(II) complex bound to the thymine bulge.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article