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[Effect of lysyl oxidase on migration and adhesion of human gastric cancer HGC-27 cells in vitro].
Ma, Bai-jing; Huang, Ling; Han, Mei; Wang, Yu-qiao; Zhao, Jian-ning; Sun, Bo-jian; Lin, Jia-jing; Song, Ting-ge.
Afiliação
  • Ma BJ; Department of Pathogenic Biology and Immunology, Ningxia Medical University, Yinchuan 750004, China.
Zhonghua Zhong Liu Za Zhi ; 33(5): 331-3, 2011 May.
Article em Zh | MEDLINE | ID: mdl-21875459
OBJECTIVE: To study the effects of lysyl oxidase (LOX) on the migration and adhesion of the human gastric cancer cell line HGC-27 cells in vitro. METHODS: The human gastric cancer cell line HGC-27 cells were cultured in vitro, and treated with different concentration of ß-aminopropionitrile (BAPN). The ability of migration was assessed by wound-healing assay. The ability of adhesion was detected by homogenous and heterogeneous adhesion experiments. RESULTS: Compared that with 0 mmol/L BAPN, the ability of migration of the cells after treatment with 0.2 mmol/L BAPN was descended at 8, 24, 32 and 48 h; the number of cells with homogeneous adhesion was increased from (6.97 ± 0.07) × 10(3)/ml to (7.78 ± 0.11) × 10(3)/ml; and the number of cells with heterogeneous adhesion was decreased from (8.98 ± 0.15) × 10(3)/ml to (8.35 ± 0.10) × 10(3)/ml, both < 0.05. Compared with that of cells treated with 0 mmol/L and 0.2 mmol/L BAPN, the migration ability of cells after treatment with 0.3 mmol/L BAPN was descended at 8, 24, 32 and 48 h; the number of cells with homogeneous adhesion was raised to (8.02 ± 0.11) × 10(3)/ml and the number of cells with heterogeneous adhesion was down to (7.93 ± 0.07) × 10(3)/ml (P < 0.05). CONCLUSION: LOX may promote the metastasis of cancer cells by enhancing invasion, increasing heterogeneous adhesion and decreasing homogeneous adhesion.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: Zh Ano de publicação: 2011 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: Zh Ano de publicação: 2011 Tipo de documento: Article