FISH analysis reveals frequent co-occurrence of 4q24/TET2 and 5q and/or 7q deletions.
Leuk Res
; 36(1): 37-41, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-21920603
ABSTRACT
We investigated TET2 deletion in 418 patients with hematological malignancies. Overall interphase FISH detected complete or partial TET2 monoallelic deletion (TET2(del)) in 20/418 cases (4.7%). TET2(del) was very rare in lymphoid malignancies (1/242 cases; 0.4%). Among 19 positive myeloid malignancies TET2(del) was associated with a 4q24 karyotypic abnormality in 18 cases. In AML, TET2(del) occurred in CD34-positive hematopoietic precursors and preceded established genomic abnormalities, such as 5q- and -7/7q-, which were the most frequent associated changes (Fisher's exact test P=0.000).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Aged
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Aged80
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article