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Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.
Liu, Qingsong; Kirubakaran, Sivapriya; Hur, Wooyoung; Niepel, Mario; Westover, Kenneth; Thoreen, Carson C; Wang, Jinhua; Ni, Jing; Patricelli, Matthew P; Vogel, Kurt; Riddle, Steve; Waller, David L; Traynor, Ryan; Sanda, Takaomi; Zhao, Zheng; Kang, Seong A; Zhao, Jean; Look, A Thomas; Sorger, Peter K; Sabatini, David M; Gray, Nathanael S.
Afiliação
  • Liu Q; Department of Cancer Biology, Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
  • Kirubakaran S; Department of Cancer Biology, Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
  • Hur W; Department of Cancer Biology, Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
  • Niepel M; Center for Cell Decision Processes, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115.
  • Westover K; Harvard Radiation Oncology Program, Boston, Massachusetts 02115.
  • Thoreen CC; Department of Cancer Biology, Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
  • Wang J; Department of Cancer Biology, Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
  • Ni J; Department of Cancer Biology, Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
  • Patricelli MP; ActivX Biosciences, Inc., La Jolla, California 92037.
  • Vogel K; Invitrogen Corp., Madison, Wisconsin 53719.
  • Riddle S; Invitrogen Corp., Madison, Wisconsin 53719.
  • Waller DL; Department of Cancer Biology, Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
  • Traynor R; National Centre for Protein Kinase Profiling, Dundee Division of Signal Transduction Therapy, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.
  • Sanda T; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215.
  • Zhao Z; High Magnetic Field Laboratory, Chinese Academy of Science, P. O. Box 1110, Hefei, Anhui, 230031, China.
  • Kang SA; Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, and; Koch Center for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
  • Zhao J; Department of Cancer Biology, Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
  • Look AT; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215.
  • Sorger PK; Center for Cell Decision Processes, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115.
  • Sabatini DM; Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, and; Koch Center for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambrid
  • Gray NS; Department of Cancer Biology, Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115. Electronic address: Nathanael_Gray@dfci.harvard.edu.
J Biol Chem ; 287(13): 9742-9752, 2012 Mar 23.
Article em En | MEDLINE | ID: mdl-22223645
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2012 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2012 Tipo de documento: Article