Androgen deprivation therapy for prostate cancer does not increase cardiovascular mortality in the long term.
Oncology
; 82(1): 56-8, 2012.
Article
em En
| MEDLINE
| ID: mdl-22310055
ABSTRACT
OBJECTIVE:
To determine if 6 months of neo-adjuvant androgen deprivation is associated with the long-term risk of cardiac mortality.METHODS:
In the TROG 96.01 trial, 802 men with locally advanced prostate cancer were randomized to radiotherapy either alone or with 3 or 6 months of neo-adjuvant androgen deprivation therapy (NADT). Competing risk methodology was used to derive the cumulative incidence of fatal cardiac events.RESULTS:
At 10 years, the cumulative incidence of fatal cardiac events for the radiation therapy alone arm was 7.54% compared to a nonstatistically significant decreased incidence of 6.44% in the 6-month NADT arm (p = 0.65). Men aged over 65 years were not at an increased risk. Additional androgen deprivation therapy given as secondary treatment at tumor progression did not confer an increased risk.CONCLUSION:
These data suggest that fatal cardiac events are not more common in men receiving up to 6 months of NADT.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article