From a multipotent stilbene to soluble epoxide hydrolase inhibitors with antiproliferative properties.

ABSTRACT

Inspired by nature Natural product isopropylstilbene was identified as an inhibitor of soluble epoxide hydrolase exhibiting antiproliferative properties. Following the natural product inspired design approach, a library of (E)-styryl-1H-benzo[d]imidazoles was synthesized and evaluated with recombinant enzyme and on several cancer cell lines.