Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies.

Choe, Chi-un; Atzler, Dorothee; Wild, Philipp S; Carter, Angela M; Böger, Rainer H; Ojeda, Francisco; Simova, Olga; Stockebrand, Malte; Lackner, Karl; Nabuurs, Christine; Marescau, Bart; Streichert, Thomas; Müller, Christian; Lüneburg, Nicole; De Deyn, Peter P; Benndorf, Ralf A; Baldus, Stephan; Gerloff, Christian; Blankenberg, Stefan; Heerschap, Arend; Grant, Peter J; Magnus, Tim; Zeller, Tanja; Isbrandt, Dirk; Schwedhelm, Edzard

Choe, Chi-un; Atzler, Dorothee; Wild, Philipp S; Carter, Angela M; Böger, Rainer H; Ojeda, Francisco; Simova, Olga; Stockebrand, Malte; Lackner, Karl; Nabuurs, Christine; Marescau, Bart; Streichert, Thomas; Müller, Christian; Lüneburg, Nicole; De Deyn, Peter P; Benndorf, Ralf A; Baldus, Stephan; Gerloff, Christian; Blankenberg, Stefan; Heerschap, Arend; Grant, Peter J; Magnus, Tim; Zeller, Tanja; Isbrandt, Dirk; Schwedhelm, Edzard.

Afiliação

Choe CU; Departments of Neurology (C.C., O.S., C.G., T.M.), Experimental Neuropediatrics (C.C., M.S., D.I.), Department of Clinical Pharmacology and Toxicology (D.A., R.H.B., N.L., R.A.B., E.S.), and German Center for Cardiovascular Research (D.A., P.S.W., R.H.B., S.B., T.Z., E.S.), Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany (F.O., C.M., S. Baldus, S. Blankenberg, T.Z.); Department of Clinical Chemistry, University Medical Center Hamburg-Eppendorf,

Circulation ; 128(13): 1451-61, 2013 Sep 24.

Article em En | MEDLINE | ID: mdl-24004504

Assuntos

Amidinotransferases/genética; Arginina/genética; Homoarginina/genética; Acidente Vascular Cerebral/genética; Adulto; Idoso; Animais; Estudos de Coortes; Modelos Animais de Doenças; Feminino; Estudo de Associação Genômica Ampla; Células HEK293; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Pessoa de Meia-Idade; Polimorfismo de Nucleotídeo Único/genética; Estudos Prospectivos; Acidente Vascular Cerebral/diagnóstico; Resultado do Tratamento

Palavras-chave

L-arginine:glycine amidinotransferase; genome-wide association studies; homoarginine; single nucleotide polymorphism; stroke

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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