Prevention by metformin of alterations induced by chronic exposure to high glucose in human islet beta cells is associated with preserved ATP/ADP ratio.

Masini, M; Anello, M; Bugliani, M; Marselli, L; Filipponi, F; Boggi, U; Purrello, F; Occhipinti, M; Martino, L; Marchetti, P; De Tata, V

Masini, M; Anello, M; Bugliani, M; Marselli, L; Filipponi, F; Boggi, U; Purrello, F; Occhipinti, M; Martino, L; Marchetti, P; De Tata, V.

Afiliação

Masini M; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy.
Anello M; Department of Clinical and Molecular Biomedicine, University of Catania, Italy.
Bugliani M; Department of Clinical and Experimental Medicine, University of Pisa, Italy.
Marselli L; Department of Clinical and Experimental Medicine, University of Pisa, Italy.
Filipponi F; Department of Surgical Pathology, Medicine, Molecular and Critical Area, University of Pisa, Italy.
Boggi U; Department of Surgical Pathology, Medicine, Molecular and Critical Area, University of Pisa, Italy.
Purrello F; Department of Clinical and Molecular Biomedicine, University of Catania, Italy.
Occhipinti M; Department of Clinical and Experimental Medicine, University of Pisa, Italy.
Martino L; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy.
Marchetti P; Department of Clinical and Experimental Medicine, University of Pisa, Italy.
De Tata V; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy. Electronic address: vincenzo.detata@med.unipi.it.

Diabetes Res Clin Pract ; 104(1): 163-70, 2014 Apr.

Article em En | MEDLINE | ID: mdl-24462282

Assuntos

Diabetes Mellitus/prevenção & controle; Glucose/efeitos adversos; Hipoglicemiantes/farmacologia; Células Secretoras de Insulina/efeitos dos fármacos; Insulina/metabolismo; Metformina/farmacologia; Difosfato de Adenosina/metabolismo; Trifosfato de Adenosina/metabolismo; Células Cultivadas; Diabetes Mellitus/sangue; Diabetes Mellitus/patologia; Feminino; Humanos; Secreção de Insulina; Células Secretoras de Insulina/ultraestrutura; Masculino; Microscopia Eletrônica; Pessoa de Meia-Idade

Palavras-chave

Adenine nucleotides; Beta cells; Diabetes; Glucotoxicity; Insulin secretion; Metformin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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