Radical cyclization/ipso-1,4-aryl migration cascade: asymmetric synthesis of 3,3-difluoro-2-propanoylbicyclo[3.3.0]octanes.

Thaharn, Watcharaporn; Soorukram, Darunee; Kuhakarn, Chutima; Tuchinda, Patoomratana; Reutrakul, Vichai; Pohmakotr, Manat

Thaharn, Watcharaporn; Soorukram, Darunee; Kuhakarn, Chutima; Tuchinda, Patoomratana; Reutrakul, Vichai; Pohmakotr, Manat.

Afiliação

Thaharn W; Center of Excellence for Innovation in Chemistry (PERCH-CIC) and Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400 (Thailand).

Angew Chem Int Ed Engl ; 53(8): 2212-5, 2014 Feb 17.

Article em En | MEDLINE | ID: mdl-24478184

ABSTRACT

ABSTRACT

A novel method for the asymmetric synthesis of 3,3-difluoro-2-propanoylbicyclo-[3.3.0]octanes involves an unprecedented intramolecular radical cyclization/ipso-1,4-aryl migration cascade.

Palavras-chave

cyclization; fluorine; radical reactions; reaction mechanism; synthetic methods

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2014 Tipo de documento: Article