Structure and function of the catalytic domain of the dihydrolipoyl acetyltransferase component in Escherichia coli pyruvate dehydrogenase complex.

Wang, Junjie; Nemeria, Natalia S; Chandrasekhar, Krishnamoorthy; Kumaran, Sowmini; Arjunan, Palaniappa; Reynolds, Shelley; Calero, Guillermo; Brukh, Roman; Kakalis, Lazaros; Furey, William; Jordan, Frank

Wang, Junjie; Nemeria, Natalia S; Chandrasekhar, Krishnamoorthy; Kumaran, Sowmini; Arjunan, Palaniappa; Reynolds, Shelley; Calero, Guillermo; Brukh, Roman; Kakalis, Lazaros; Furey, William; Jordan, Frank.

Afiliação

Wang J; From the Department of Chemistry, Rutgers University, Newark, New Jersey 07102.
Nemeria NS; From the Department of Chemistry, Rutgers University, Newark, New Jersey 07102.
Chandrasekhar K; the Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261.
Kumaran S; From the Department of Chemistry, Rutgers University, Newark, New Jersey 07102.
Arjunan P; the Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261.
Reynolds S; the Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261.
Calero G; the Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261.
Brukh R; From the Department of Chemistry, Rutgers University, Newark, New Jersey 07102.
Kakalis L; From the Department of Chemistry, Rutgers University, Newark, New Jersey 07102.
Furey W; the Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, the Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, and fureyw@pitt.edu.
Jordan F; From the Department of Chemistry, Rutgers University, Newark, New Jersey 07102, frjordan@rutgers.edu.

J Biol Chem ; 289(22): 15215-30, 2014 May 30.

Article em En | MEDLINE | ID: mdl-24742683

Assuntos

Di-Hidrolipoil-Lisina-Resíduo Acetiltransferase/metabolismo; Proteínas de Escherichia coli/metabolismo; Escherichia coli/enzimologia; Complexo Piruvato Desidrogenase/metabolismo; Acetilcoenzima A/biossíntese; Acetilação; Sequência de Aminoácidos; Metabolismo dos Carboidratos/fisiologia; Domínio Catalítico; Cristalografia por Raios X; Medição da Troca de Deutério; Di-Hidrolipoil-Lisina-Resíduo Acetiltransferase/química; Di-Hidrolipoil-Lisina-Resíduo Acetiltransferase/genética; Ativação Enzimática/fisiologia; Escherichia coli/genética; Proteínas de Escherichia coli/química; Proteínas de Escherichia coli/genética; Dados de Sequência Molecular; Plasmídeos; Complexo Piruvato Desidrogenase/química; Complexo Piruvato Desidrogenase/genética; Ácido Pirúvico/metabolismo

Palavras-chave

Carbohydrate Metabolism; Enzyme Catalysis; HD Exchange; Mass Spectrometry (MS); Nuclear Magnetic Resonance (NMR); Pyruvate Dehydrogenase Complex (PDC); X-ray Crystallography

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article