Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action.

Kisin-Finfer, Einat; Ferber, Shiran; Blau, Rachel; Satchi-Fainaro, Ronit; Shabat, Doron

Kisin-Finfer, Einat; Ferber, Shiran; Blau, Rachel; Satchi-Fainaro, Ronit; Shabat, Doron.

Afiliação

Kisin-Finfer E; Department of Organic Chemistry, School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Ferber S; Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Blau R; Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Satchi-Fainaro R; Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Shabat D; Department of Organic Chemistry, School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: chdoron@post.tau.ac.il.

Bioorg Med Chem Lett ; 24(11): 2453-8, 2014 Jun 01.

Article em En | MEDLINE | ID: mdl-24767838

Assuntos

Catepsina B/análise; Transferência Ressonante de Energia de Fluorescência; Corantes Fluorescentes/química; Imagem Molecular; Catepsina B/metabolismo; Corantes Fluorescentes/síntese química; Corantes Fluorescentes/metabolismo; Humanos; Raios Infravermelhos; Estrutura Molecular

Palavras-chave

Cathepsin B; Cyanine dyes; Fluorescent probes; Near infrared fluorescence

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article