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The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
Chin, Randall M; Fu, Xudong; Pai, Melody Y; Vergnes, Laurent; Hwang, Heejun; Deng, Gang; Diep, Simon; Lomenick, Brett; Meli, Vijaykumar S; Monsalve, Gabriela C; Hu, Eileen; Whelan, Stephen A; Wang, Jennifer X; Jung, Gwanghyun; Solis, Gregory M; Fazlollahi, Farbod; Kaweeteerawat, Chitrada; Quach, Austin; Nili, Mahta; Krall, Abby S; Godwin, Hilary A; Chang, Helena R; Faull, Kym F; Guo, Feng; Jiang, Meisheng; Trauger, Sunia A; Saghatelian, Alan; Braas, Daniel; Christofk, Heather R; Clarke, Catherine F; Teitell, Michael A; Petrascheck, Michael; Reue, Karen; Jung, Michael E; Frand, Alison R; Huang, Jing.
Afiliação
  • Chin RM; Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Fu X; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Pai MY; 1] Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095, USA [2].
  • Vergnes L; 1] Department of Human Genetics, University of California Los Angeles, Los Angeles, California 90095, USA [2].
  • Hwang H; 1] Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California 90095, USA [2].
  • Deng G; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Diep S; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Lomenick B; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Meli VS; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Monsalve GC; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Hu E; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Whelan SA; Department of Surgery, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Wang JX; Small Molecule Mass Spectrometry Facility, FAS Division of Science, Harvard University, Cambridge, Massachusetts 02138, USA.
  • Jung G; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Solis GM; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA.
  • Fazlollahi F; Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Kaweeteerawat C; Department of Environmental Health Sciences, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Quach A; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Nili M; Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Krall AS; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Godwin HA; Department of Environmental Health Sciences, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Chang HR; Department of Surgery, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Faull KF; Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Guo F; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Jiang M; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Trauger SA; Small Molecule Mass Spectrometry Facility, FAS Division of Science, Harvard University, Cambridge, Massachusetts 02138, USA.
  • Saghatelian A; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
  • Braas D; 1] Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California 90095, USA [2] UCLA Metabolomics Center, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Christofk HR; 1] Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California 90095, USA [2] UCLA Metabolomics Center, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Clarke CF; 1] Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095, USA [2] Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Teitell MA; 1] Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095, USA [2] Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Petrascheck M; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA.
  • Reue K; 1] Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095, USA [2] Department of Human Genetics, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Jung ME; 1] Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095, USA [2] Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Frand AR; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Huang J; 1] Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095, USA [2] Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California 90095, USA.
Nature ; 510(7505): 397-401, 2014 Jun 19.
Article em En | MEDLINE | ID: mdl-24828042
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article