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Amino alcohols from the ascidian Pseudodistoma sp.
Won, Tae Hyung; You, Minjung; Lee, So-Hyoung; Rho, Boon Jo; Oh, Dong-Chan; Oh, Ki-Bong; Shin, Jongheon.
Afiliação
  • Won TH; Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. wth123@snu.ac.kr.
  • You M; Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. lovemin90@snu.ac.kr.
  • Lee SH; Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea. awhee84@naver.com.
  • Rho BJ; Department of Biological Science, College of Life Science, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun, Seoul 120-750, Korea. nhm@ewha.ac.kr.
  • Oh DC; Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. dongchanoh@snu.ac.kr.
  • Oh KB; Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea. awhee84@naver.com.
  • Shin J; Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. shinj@snu.ac.kr.
Mar Drugs ; 12(6): 3754-69, 2014 Jun 24.
Article em En | MEDLINE | ID: mdl-24962272
ABSTRACT
Seven new amino alcohol compounds, pseudoaminols A-G (1-7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxymethyl group in two of the new compounds (6 and 7) is unprecedented among amino alcohols. Several of these compounds exhibited moderate antimicrobial activity and cytotoxicity, as well as weak inhibitory activity toward Na+/K+-ATPase.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans País/Região como assunto: Asia Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans País/Região como assunto: Asia Idioma: En Ano de publicação: 2014 Tipo de documento: Article