Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model.

Xu, Gaoya; Ji, Weidan; Su, Yinghan; Xu, Yang; Yan, Yan; Shen, Shuwen; Li, Xiaoya; Sun, Bin; Qian, Haihua; Chen, Lei; Fu, Xiaohui; Wu, Mengchao; Su, Changqing

Xu, Gaoya; Ji, Weidan; Su, Yinghan; Xu, Yang; Yan, Yan; Shen, Shuwen; Li, Xiaoya; Sun, Bin; Qian, Haihua; Chen, Lei; Fu, Xiaohui; Wu, Mengchao; Su, Changqing.

Afiliação

Xu G; Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, The Second Military Medical University, Shanghai, China. Department of Pathogen Biology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou, China.
Ji W; Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, The Second Military Medical University, Shanghai, China.
Su Y; Department of Biology, Xi'an Jiaotong-Liverpool University, Suzhou, China.
Xu Y; Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, The Second Military Medical University, Shanghai, China.
Yan Y; Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, The Second Military Medical University, Shanghai, China.
Shen S; Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, The Second Military Medical University, Shanghai, China.
Li X; Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, The Second Military Medical University, Shanghai, China.
Sun B; Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, The Second Military Medical University, Shanghai, China.
Qian H; Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, The Second Military Medical University, Shanghai, China.
Chen L; Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, The Second Military Medical University, Shanghai, China.
Fu X; Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, The Second Military Medical University, Shanghai, China.
Wu M; Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, The Second Military Medical University, Shanghai, China.
Su C; Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, The Second Military Medical University, Shanghai, China. Department of Pathogen Biology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou, China.

Oncotarget ; 5(13): 5029-39, 2014 Jul 15.

Article em En | MEDLINE | ID: mdl-24970807

Assuntos

Carcinoma Hepatocelular/tratamento farmacológico; Fator 2 de Crescimento de Fibroblastos/farmacologia; Neoplasias Hepáticas/tratamento farmacológico; Transdução de Sinais/efeitos dos fármacos; Sulfotransferases/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto/métodos; Animais; Apoptose/efeitos dos fármacos; Apoptose/genética; Western Blotting; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/metabolismo; Ciclo Celular/efeitos dos fármacos; Ciclo Celular/genética; Linhagem Celular; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Sobrevivência Celular/genética; Ciclina D1/genética; Ciclina D1/metabolismo; Humanos; Imuno-Histoquímica; Proteínas Inibidoras de Apoptose/genética; Proteínas Inibidoras de Apoptose/metabolismo; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Camundongos Endogâmicos BALB C; Camundongos Nus; Proteína Quinase 3 Ativada por Mitógeno/genética; Proteína Quinase 3 Ativada por Mitógeno/metabolismo; Proteínas Proto-Oncogênicas c-akt/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Interferência de RNA; Transdução de Sinais/genética; Sulfotransferases/genética; Survivina; Carga Tumoral/efeitos dos fármacos; Carga Tumoral/genética

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article