Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase.

Samson, Andre L; Knaupp, Anja S; Kass, Itamar; Kleifeld, Oded; Marijanovic, Emilia M; Hughes, Victoria A; Lupton, Chris J; Buckle, Ashley M; Bottomley, Stephen P; Medcalf, Robert L

Samson, Andre L; Knaupp, Anja S; Kass, Itamar; Kleifeld, Oded; Marijanovic, Emilia M; Hughes, Victoria A; Lupton, Chris J; Buckle, Ashley M; Bottomley, Stephen P; Medcalf, Robert L.

Afiliação

Samson AL; Australian Centre for Blood Diseases, Monash University, Melbourne 3004, Victoria, Australia and; Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia. Electronic address: andre.samson@monash.edu.
Knaupp AS; Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia; Australian Regenerative Medicine Institute and Department of Anatomy and Developmental Biology, and Monash University, Clayton 3800, Victoria, Australia.
Kass I; Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia; Victorian Life Sciences Computation Centre, Monash University, Clayton 3800, Victoria, Australia.
Kleifeld O; Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia.
Marijanovic EM; Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia.
Hughes VA; Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia.
Lupton CJ; Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia.
Buckle AM; Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia.
Bottomley SP; Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia.
Medcalf RL; Australian Centre for Blood Diseases, Monash University, Melbourne 3004, Victoria, Australia and. Electronic address: robert.medcalf@monash.edu.

J Biol Chem ; 289(39): 26922-26936, 2014 Sep 26.

Article em En | MEDLINE | ID: mdl-25086035

Assuntos

Gliceraldeído-3-Fosfato Desidrogenases/química; Metionina/química; Modelos Moleculares; Agregação Patológica de Proteínas; Dobramento de Proteína; Processamento de Proteína Pós-Traducional; Substituição de Aminoácidos; Gliceraldeído-3-Fosfato Desidrogenases/genética; Gliceraldeído-3-Fosfato Desidrogenases/metabolismo; Humanos; Metionina/genética; Metionina/metabolismo; Mutação de Sentido Incorreto; Oxirredução

Palavras-chave

Disulfide; GAPDH; Molecular Dynamics; Nucleocytoplasmic Coagulation; Oxidative Stress; Post-translational Modification (PTM); Protein Aggregation; Protein Misfolding

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article