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In vitro combination of isavuconazole with micafungin or amphotericin B deoxycholate against medically important molds.
Katragkou, Aspasia; McCarthy, Matthew; Meletiadis, Joseph; Petraitis, Vidmantas; Moradi, Patriss W; Strauss, Gittel E; Fouant, Monique M; Kovanda, Laura L; Petraitiene, Ruta; Roilides, Emmanuel; Walsh, Thomas J.
Afiliação
  • Katragkou A; Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA.
  • McCarthy M; Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA.
  • Meletiadis J; Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Petraitis V; Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA.
  • Moradi PW; Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA.
  • Strauss GE; Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA.
  • Fouant MM; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA.
  • Kovanda LL; Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA.
  • Petraitiene R; Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA.
  • Roilides E; Infectious Disease Unit, 3rd Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Hippokration Hospital, Thessaloniki, Greece.
  • Walsh TJ; Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA Department of Pediatrics, Weill Cornell Medical College of Cornell University, New York, New York, USA Department
Antimicrob Agents Chemother ; 58(11): 6934-7, 2014 Nov.
Article em En | MEDLINE | ID: mdl-25136021
ABSTRACT
Whether isavuconazole, an extended-spectrum triazole, possesses synergistic activity in combination therapy with echinocandins or amphotericin B for the treatment of invasive molds infections has not been studied. Our in vitro combination studies showed that isavuconazole and micafungin are synergistically active against Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, and Cunninghamella bertholletiae. These results suggest that isavuconazole, in combination with micafungin, may have a role in the treatment of invasive aspergillosis and warrants further investigation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2014 Tipo de documento: Article