Influence of adverse drug events on morbidity and mortality in intensive care units: the JADE study.
Int J Qual Health Care
; 26(6): 573-8, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25192926
ABSTRACT
OBJECTIVE:
To identify the influence of adverse drug events (ADEs) on morbidity and mortality in intensive care units (ICUs).DESIGN:
A prospective cohort study.SETTING:
ICU setting at three acute care hospitals in Japan.PARTICIPANTS:
All patients aged ≥15 years were admitted to all ICUs during a 6-month study period. INTERVENTION No intervention. MAIN OUTCOMEMEASURES:
Mortality in the ICUs and the length of the ICU stay. .RESULTS:
We included 459 patients with a total of 3231 patient-days. Ninety-nine ADEs occurred in 70 patients (15%), so that the incidence of ADEs was 30.6 per 1000 patient-days and 21.6 ADEs per 100 admissions. Seventy-three patients (16%) died during their ICU stay. Excluding 38 deaths within 3 days after admission, 12 patients (17%) died among the 70 patients who had at least one ADE during their ICU stay and 23 (7%) died among 351 without an ADE (P = 0.003). The median ICU length of stay was 3 days. Excluding 73 patients who died during their ICU stay, the median ICU stay of patients with at least one ADE was 13 days, while it was only 2 days in the remainder (P < 0.0001). ADEs were associated with longer length of ICU stay but not with mortality even after adjusting for patients' severity of illness.CONCLUSIONS:
ADEs were common in ICUs and significantly associated with longer length of ICU stay but did not influence on mortality.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
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Incidence_studies
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Observational_studies
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Prognostic_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article