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A longitudinal comparison of hemodynamics and intraluminal thrombus deposition in abdominal aortic aneurysms.
Arzani, Amirhossein; Suh, Ga-Young; Dalman, Ronald L; Shadden, Shawn C.
Afiliação
  • Arzani A; Mechanical Engineering, University of California, Berkeley, California; and.
  • Suh GY; Division of Vascular Surgery, Stanford University, Stanford, California.
  • Dalman RL; Division of Vascular Surgery, Stanford University, Stanford, California.
  • Shadden SC; Mechanical Engineering, University of California, Berkeley, California; and shadden@berkeley.edu.
Am J Physiol Heart Circ Physiol ; 307(12): H1786-95, 2014 Dec 15.
Article em En | MEDLINE | ID: mdl-25326533
ABSTRACT
Abdominal aortic aneurysm (AAA) is often accompanied by in traluminal thrombus (ILT), which complicates AAA progression and risk of rupture. Patient-specific computational fluid dynamics modeling of 10 small human AAA was performed to investigate relations between hemodynamics and ILT progression. The patients were imaged using magnetic resonance twice in a 2- to 3-yr interval. Wall content data were obtained by a planar T1-weighted fast spin echo black-blood scan, which enabled quantification of thrombus thickness at midaneurysm location during baseline and followup. Computational simulations with patient-specific geometry and boundary conditions were performed to quantify the hemodynamic parameters of time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), and mean exposure time at baseline. Spatially resolved quantifications of the change in ILT thickness were compared with the different hemodynamic parameters. Regions of low OSI had the strongest correlation with ILT growth and demonstrated a statistically significant correlation coefficient. Prominent regions of high OSI (>0.4) and low TAWSS (<1 dyn/cm(2)) did not appear to coincide with locations of thrombus deposition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article