Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis.

Nammalwar, Baskar; Bourne, Christina R; Wakeham, Nancy; Bourne, Philip C; Barrow, Esther W; Muddala, N Prasad; Bunce, Richard A; Berlin, K Darrell; Barrow, William W

Nammalwar, Baskar; Bourne, Christina R; Wakeham, Nancy; Bourne, Philip C; Barrow, Esther W; Muddala, N Prasad; Bunce, Richard A; Berlin, K Darrell; Barrow, William W.

Afiliação

Nammalwar B; Department of Chemistry, Oklahoma State University, 107 Physical Sciences, Stillwater, OK 74078, USA.
Bourne CR; Department of Veterinary Pathobiology, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA.
Wakeham N; Department of Veterinary Pathobiology, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA.
Bourne PC; Department of Veterinary Pathobiology, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA.
Barrow EW; Department of Veterinary Pathobiology, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA.
Muddala NP; Department of Chemistry, Oklahoma State University, 107 Physical Sciences, Stillwater, OK 74078, USA.
Bunce RA; Department of Chemistry, Oklahoma State University, 107 Physical Sciences, Stillwater, OK 74078, USA. Electronic address: rab@okstate.edu.
Berlin KD; Department of Chemistry, Oklahoma State University, 107 Physical Sciences, Stillwater, OK 74078, USA.
Barrow WW; Department of Veterinary Pathobiology, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA.

Bioorg Med Chem ; 23(1): 203-11, 2015 Jan 01.

Article em En | MEDLINE | ID: mdl-25435253

Assuntos

Antibacterianos/química; Bacillus anthracis/enzimologia; Antagonistas do Ácido Fólico/química; Pirimidinas/química; Antibacterianos/farmacologia; Antagonistas do Ácido Fólico/farmacologia; Modelos Moleculares; Ligação Proteica; Pirimidinas/farmacologia; Relação Estrutura-Atividade

Palavras-chave

Antibiotics; Antifolates; Antimicrobial agents; Bacillus anthracis inhibition; Dihydrofolate reductase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article