A novel 96-well multielectrode array based impedimetric monitoring platform for comparative drug efficacy analysis on 2D and 3D brain tumor cultures.

Eichler, Marie; Jahnke, Heinz-Georg; Krinke, Dana; Müller, Astrid; Schmidt, Sabine; Azendorf, Ronny; Robitzki, Andrea A

Eichler, Marie; Jahnke, Heinz-Georg; Krinke, Dana; Müller, Astrid; Schmidt, Sabine; Azendorf, Ronny; Robitzki, Andrea A.

Afiliação

Eichler M; Center for Biotechnology and Biomedicine (BBZ), University of Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Deutscher Platz 5, 04103 Leipzig, Germany.
Jahnke HG; Center for Biotechnology and Biomedicine (BBZ), University of Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Deutscher Platz 5, 04103 Leipzig, Germany.
Krinke D; Center for Biotechnology and Biomedicine (BBZ), University of Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Deutscher Platz 5, 04103 Leipzig, Germany.
Müller A; Center for Biotechnology and Biomedicine (BBZ), University of Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Deutscher Platz 5, 04103 Leipzig, Germany.
Schmidt S; Center for Biotechnology and Biomedicine (BBZ), University of Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Deutscher Platz 5, 04103 Leipzig, Germany.
Azendorf R; Center for Biotechnology and Biomedicine (BBZ), University of Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Deutscher Platz 5, 04103 Leipzig, Germany.
Robitzki AA; Center for Biotechnology and Biomedicine (BBZ), University of Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Deutscher Platz 5, 04103 Leipzig, Germany. Electronic address: andrea.robitzki@bbz.uni-leipzig.de.

Biosens Bioelectron ; 67: 582-9, 2015 May 15.

Article em En | MEDLINE | ID: mdl-25445619

Assuntos

Técnicas Biossensoriais; Neoplasias Encefálicas/tratamento farmacológico; Espectroscopia Dielétrica; Glioblastoma/tratamento farmacológico; Apoptose; Neoplasias Encefálicas/patologia; Linhagem Celular Tumoral; Doxorrubicina/administração & dosagem; Etoposídeo/administração & dosagem; Glioblastoma/patologia; Humanos; Esferoides Celulares; Vincristina/administração & dosagem

Palavras-chave

3D brain tumor models; 96-well-multielectrode array; Drug efficacy monitoring; Impedance spectroscopy; Microcavity array

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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