Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates.

Hillman, Sara L; Finer, Sarah; Smart, Melissa C; Mathews, Chris; Lowe, Robert; Rakyan, Vardhman K; Hitman, Graham A; Williams, David J

Hillman, Sara L; Finer, Sarah; Smart, Melissa C; Mathews, Chris; Lowe, Robert; Rakyan, Vardhman K; Hitman, Graham A; Williams, David J.

Afiliação

Hillman SL; a Institute for Women's Health ; University College London ; London , UK.

Epigenetics ; 10(1): 50-61, 2015.

Article em En | MEDLINE | ID: mdl-25496377

Assuntos

Metilação de DNA; Epigênese Genética; Retardo do Crescimento Fetal/genética; Ativação Transcricional; Adulto; Estudos de Casos e Controles; Feminino; Sangue Fetal/metabolismo; Retardo do Crescimento Fetal/epidemiologia; Regulação da Expressão Gênica no Desenvolvimento; Genoma Humano; Humanos; Recém-Nascido; Masculino; Placenta/metabolismo; Gravidez

Palavras-chave

AGA, appropriately grown offspring; BMI, body mass index; CG, cytosine phosphate guanine loci; DMP, differentially methylated positions; DNA methylation; FDR, false discovery rate; FGR, fetal growth restriction; GO, gene ontology; HOMA, homeostasis model assessment; ICR1, imprinting control region 1; MODY, maturity onset diabetes of the young; Marmal-aid; T2DM, type 2 diabetes mellitus; UCL, University College London; UCLH, University College London Hospital; UCSC, University of California Santa Cruz; fetal growth restriction; fetal origins of adult disease; placenta; transcription factor; umbilical cord

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Newborn / Pregnancy Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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