Oral Papillomas Associated With Felis catus Papillomavirus Type 1 in 2 Domestic Cats.
Vet Pathol
; 52(6): 1187-90, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-25572261
ABSTRACT
Multiple small sessile raised lesions were detected on the ventral surface of the tongue in two 13-year-old domestic cats. The lesions were incidental in both cats. Lesions from both cats appeared histologically as well-demarcated foci of markedly thickened folded epithelium that formed keratin-filled shallow cuplike structures. Large keratinocytes that contained a swollen nucleus surrounded by a clear cytoplasmic halo (koilocytes) were common, suggesting a diagnosis of a papillomavirus-induced papillomas, and papillomavirus antigen was demonstrated by immunohistochemistry. The papillomas exhibited diffuse intense cytoplasmic and nuclear immunoreactivity against cyclin-dependent kinase inhibitor 2A protein (also known as p16 or INK4a protein). Felis catus papillomavirus type 1 DNA sequences were amplified from both papillomas. The papillomas resolved in 1 cat within 3 months of diagnosis, while the papillomas were still visible 4 months after diagnosis in the other cat. This is the first evidence that these papillomas are caused by F. catus papillomavirus type 1.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article