Endothelin-1 upregulation mediates aging-related cardiac fibrosis.

Wang, Xianwei; Guo, Zhikun; Ding, Zufeng; Khaidakov, Magomed; Lin, Juntang; Xu, Zhenping; Sharma, Shree G; Jiwani, Shahanawaz; Mehta, Jawahar L

Wang, Xianwei; Guo, Zhikun; Ding, Zufeng; Khaidakov, Magomed; Lin, Juntang; Xu, Zhenping; Sharma, Shree G; Jiwani, Shahanawaz; Mehta, Jawahar L.

Afiliação

Wang X; Central Arkansas Veterans Healthcare System, Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Key Laboratory of Henan province for Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, Henan, China. Electronic address: Xwang2@uams.edu.
Guo Z; Key Laboratory of Henan province for Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, Henan, China.
Ding Z; Central Arkansas Veterans Healthcare System, Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Khaidakov M; Central Arkansas Veterans Healthcare System, Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Lin J; Key Laboratory of Henan province for Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, Henan, China.
Xu Z; Key Laboratory of Henan province for Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, Henan, China.
Sharma SG; Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Jiwani S; Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Mehta JL; Central Arkansas Veterans Healthcare System, Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: MehtaJL@UAMS.edu.

J Mol Cell Cardiol ; 80: 101-9, 2015 Mar.

Article em En | MEDLINE | ID: mdl-25584774

Assuntos

Envelhecimento/genética; Endotelina-1/genética; Regulação da Expressão Gênica; Miocárdio/metabolismo; Miocárdio/patologia; Animais; Ácido Aspártico Endopeptidases/antagonistas & inibidores; Ácido Aspártico Endopeptidases/metabolismo; Senescência Celular/genética; Endotelina-1/metabolismo; Enzimas Conversoras de Endotelina; Ativação Enzimática; Receptor alfa de Estrogênio/genética; Receptor alfa de Estrogênio/metabolismo; Feminino; Fibroblastos/efeitos dos fármacos; Fibroblastos/metabolismo; Fibrose; Técnicas de Silenciamento de Genes; Humanos; Metaloendopeptidases/antagonistas & inibidores; Metaloendopeptidases/metabolismo; Camundongos; Interferência de RNA; Transdução de Sinais; Regulação para Cima; beta-Galactosidase/metabolismo

Palavras-chave

Aging; Cardiac fibrosis; Collagens; Endothelin-1; Fibronectin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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