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Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?
Mesens, Natalie; Crawford, Alexander D; Menke, Aswin; Hung, Pham Duc; Van Goethem, Freddy; Nuyts, Rik; Hansen, Erik; Wolterbeek, Andre; Van Gompel, Jacky; De Witte, Peter; Esguerra, Camila V.
Afiliação
  • Mesens N; Discovery Support and Investigative Toxicology group EU, Preclinical Development and Safety, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340, Beerse, Belgium.
  • Crawford AD; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven Campus Gasthuisberg, O&N 2, 08.4226 Herestraat 49, PB 824, 3000, Leuven, Belgium.
  • Menke A; TNO, Utrechtseweg 48, 3704HE, Zeist, The Netherlands.
  • Hung PD; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven Campus Gasthuisberg, O&N 2, 08.4226 Herestraat 49, PB 824, 3000, Leuven, Belgium.
  • Van Goethem F; Discovery Support and Investigative Toxicology group EU, Preclinical Development and Safety, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340, Beerse, Belgium.
  • Nuyts R; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven Campus Gasthuisberg, O&N 2, 08.4226 Herestraat 49, PB 824, 3000, Leuven, Belgium.
  • Hansen E; Discovery Support and Investigative Toxicology group EU, Preclinical Development and Safety, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340, Beerse, Belgium.
  • Wolterbeek A; TNO, Utrechtseweg 48, 3704HE, Zeist, The Netherlands.
  • Van Gompel J; Discovery Support and Investigative Toxicology group EU, Preclinical Development and Safety, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340, Beerse, Belgium.
  • De Witte P; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven Campus Gasthuisberg, O&N 2, 08.4226 Herestraat 49, PB 824, 3000, Leuven, Belgium.
  • Esguerra CV; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven Campus Gasthuisberg, O&N 2, 08.4226 Herestraat 49, PB 824, 3000, Leuven, Belgium.
J Appl Toxicol ; 35(9): 1017-29, 2015 Sep.
Article em En | MEDLINE | ID: mdl-25663337
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article