Posttraumatic stress disorder-like induction elevates ß-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses.

Justice, Nicholas J; Huang, Longwen; Tian, Jin-Bin; Cole, Allysa; Pruski, Melissa; Hunt, Albert J; Flores, Rene; Zhu, Michael X; Arenkiel, Benjamin R; Zheng, Hui

Justice, Nicholas J; Huang, Longwen; Tian, Jin-Bin; Cole, Allysa; Pruski, Melissa; Hunt, Albert J; Flores, Rene; Zhu, Michael X; Arenkiel, Benjamin R; Zheng, Hui.

Afiliação

Justice NJ; Institute of Molecular Medicine, Program in Neuroscience, and Huffington Center on Aging and Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, and Nicholas.J.Justice@uth.tmc.edu.
Huang L; Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, and Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030.
Tian JB; Department of Integrative Biology and Pharmacology, University of Texas Health Sciences Center, Houston, Texas 77030.
Cole A; Huffington Center on Aging and.
Pruski M; Institute of Molecular Medicine.
Hunt AJ; Institute of Molecular Medicine, Program in Neuroscience, and.
Flores R; Institute of Molecular Medicine.
Zhu MX; Department of Integrative Biology and Pharmacology, University of Texas Health Sciences Center, Houston, Texas 77030.
Arenkiel BR; Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, and Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030.
Zheng H; Huffington Center on Aging and Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, and.

J Neurosci ; 35(6): 2612-23, 2015 Feb 11.

Article em En | MEDLINE | ID: mdl-25673853

Assuntos

Peptídeos beta-Amiloides/metabolismo; Hormônio Liberador da Corticotropina/metabolismo; Neurônios/metabolismo; Transtornos de Estresse Pós-Traumáticos/metabolismo; Estresse Psicológico/metabolismo; Corticosteroides/líquido cefalorraquidiano; Doença de Alzheimer/metabolismo; Secretases da Proteína Precursora do Amiloide/antagonistas & inibidores; Animais; Comportamento Animal; Células CHO; Cricetulus; Técnicas de Introdução de Genes; Camundongos; Cultura Primária de Células; Transtornos de Estresse Pós-Traumáticos/psicologia; Estresse Psicológico/psicologia

Palavras-chave

Alzheimer's disease; PTSD; crf; crfr1; crh; stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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