Progesterone rapidly down-regulates the biosynthesis of 5-lipoxygenase products in human primary monocytes.

Pergola, Carlo; Schaible, Anja M; Nikels, Felix; Dodt, Gabriele; Northoff, Hinnak; Werz, Oliver

Pergola, Carlo; Schaible, Anja M; Nikels, Felix; Dodt, Gabriele; Northoff, Hinnak; Werz, Oliver.

Afiliação

Pergola C; Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany. Electronic address: pergolacarlo@googlemail.com.
Schaible AM; Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany. Electronic address: anja.schaible@gmx.de.
Nikels F; Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany. Electronic address: felix.nikels@uni-jena.de.
Dodt G; Interfakultäres Institut für Biochemie, University Tuebingen, 72076 Tuebingen, Germany. Electronic address: gabriele.dodt@uni-tuebingen.de.
Northoff H; Institute for Clinical and Experimental Transfusion Medicine, University Medical Center Tuebingen, 72076 Tuebingen, Germany. Electronic address: hinnak.northoff@med.uni-tuebingen.de.
Werz O; Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany. Electronic address: oliver.werz@uni-jena.de.

Pharmacol Res ; 94: 42-50, 2015 Apr.

Article em En | MEDLINE | ID: mdl-25681061

Assuntos

Araquidonato 5-Lipoxigenase/biossíntese; Monócitos/metabolismo; Progesterona/farmacologia; Ácido Araquidônico/metabolismo; Cálcio/metabolismo; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Regulação para Baixo/efeitos dos fármacos; Humanos; Monócitos/efeitos dos fármacos; Monócitos/enzimologia; Cultura Primária de Células; Transdução de Sinais

Palavras-chave

1-Oleoyl-2-acetyl-sn-glycerol (OAG) (PubChem CID: 6437085); 5-Lipoxygenase; 8-Br-cAMP (PubChem CID: 32014); Arachidonic acid; Ca(2+)-ionophore A23187 (PubChem CID: 11957499); Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (CDC) (PubChem CID: 14840979); H89 (PubChem CID: 449241); Leukotriene; Monocytes; Progesterone; Prostaglandin E(2) (PubChem CID: 5280360); Sex differences; cPLA(2)α inhibitor RSC-3388, N-{(2S,4R)-4-(biphenyl-2-ylmethyl-isobutyl-amino)-1-[2-(2,4-difluorobenzoyl)-benzoyl]-pyrrolidin-2-ylmethyl}-3-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-phenyl]acrylamide (PubChem CID: 9833099)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article