Stereoselective Actions of Methylenedioxypyrovalerone (MDPV) To Inhibit Dopamine and Norepinephrine Transporters and Facilitate Intracranial Self-Stimulation in Rats.

Kolanos, R; Partilla, J S; Baumann, M H; Hutsell, B A; Banks, M L; Negus, S S; Glennon, R A

Kolanos, R; Partilla, J S; Baumann, M H; Hutsell, B A; Banks, M L; Negus, S S; Glennon, R A.

Afiliação

Kolanos R; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, PO Box 980540, Richmond, Virginia 23298, United States.
Partilla JS; Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, United States.
Baumann MH; Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, United States.
Hutsell BA; §Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, PO Box 980613, Richmond, Virginia 23298, United States.
Banks ML; §Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, PO Box 980613, Richmond, Virginia 23298, United States.
Negus SS; §Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, PO Box 980613, Richmond, Virginia 23298, United States.
Glennon RA; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, PO Box 980540, Richmond, Virginia 23298, United States.

ACS Chem Neurosci ; 6(5): 771-7, 2015 May 20.

Article em En | MEDLINE | ID: mdl-25688761

Assuntos

Benzodioxóis/química; Benzodioxóis/farmacologia; Encéfalo/efeitos dos fármacos; Proteínas da Membrana Plasmática de Transporte de Dopamina/antagonistas & inibidores; Proteínas da Membrana Plasmática de Transporte de Norepinefrina/antagonistas & inibidores; Pirrolidinas/química; Pirrolidinas/farmacologia; Animais; Drogas Desenhadas/química; Drogas Desenhadas/farmacologia; Masculino; Ratos; Ratos Sprague-Dawley; Autoestimulação/efeitos dos fármacos; Estereoisomerismo; Catinona Sintética

Palavras-chave

DAT; ICSS (intracranial self-stimulation); MDPV; NET; Synthetic cathinones; cocaine; drug abuse; psychomotor stimulants; reuptake inhibition

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article