Direct trifluoromethylthiolation of unactivated C(sp(3))-H using silver(I) trifluoromethanethiolate and potassium persulfate.
Angew Chem Int Ed Engl
; 54(13): 4070-4, 2015 Mar 23.
Article
em En
| MEDLINE
| ID: mdl-25707945
ABSTRACT
A practical and efficient method for the direct trifluoromethylthiolation of unactivated C(sp(3) )H bonds by AgSCF3 /K2 S2 O8 under mild conditions is described. The reaction has a good functional-group tolerance and good selectivity. Initial mechanistic investigations indicate that the reaction may involve a radical process in which K2 S2 O8 plays key roles in both the activation of the C(sp(3) )H bond and the oxidation of AgSCF3 .
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MEDLINE
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En
Ano de publicação:
2015
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Article