Mortality in cancer patients previously diagnosed with herpes zoster in the hospital setting: a nationwide cohort study.
Br J Cancer
; 112(11): 1822-6, 2015 May 26.
Article
em En
| MEDLINE
| ID: mdl-25880013
ABSTRACT
BACKGROUND:
Herpes zoster (HZ) is associated with underlying immunodeficiency and may thereby predict mortality of subsequent cancer.METHODS:
By using Danish nationwide medical databases, we identified all cancer patients with a prior hospital-based HZ diagnosis during 1982-2011 (n=2754) and a matched cancer cohort without prior HZ (n=26 243). We computed adjusted mortality rate ratios (aMRRs) associating prior HZ with mortality following cancer.RESULTS:
Prior HZ was associated with decreased mortality within the year after cancer diagnosis (aMRR 0.87; 95% confidence interval (CI) 0.81-0.93), but not thereafter (aMRR 1.07; 95% CI 0.99-1.15). However, prior HZ predicted increased mortality throughout the entire follow-up among patients aged <60 years (aMRR 1.39; 95% CI 1.15-1.68) and those with disseminated HZ (aMRR 1.18; 95% CI 1.01-1.37). The increased mortality rates were observed primarily for haematological and immune-related cancers.CONCLUSIONS:
Overall, HZ was not a predictor of increased mortality following subsequent cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article