Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II.
J Med Chem
; 58(10): 4357-63, 2015 May 28.
Article
em En
| MEDLINE
| ID: mdl-25923815
ABSTRACT
We present here a structure-aided design of inhibitors targeting the active site as well as exosites of glutamate carboxypeptidase II (GCPII), a prostate cancer marker, preparing potent and selective inhibitors that are more than 1000-fold more active toward GCPII than its closest human homologue, glutamate carboxypeptidase III (GCPIII). Additionally, we demonstrate that the prepared inhibitor conjugate can be used for sensitive and selective imaging of GCPII in mammalian cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article