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Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products.
Bockus, Andrew T; Lexa, Katrina W; Pye, Cameron R; Kalgutkar, Amit S; Gardner, Jarret W; Hund, Kathryn C R; Hewitt, William M; Schwochert, Joshua A; Glassey, Emerson; Price, David A; Mathiowetz, Alan M; Liras, Spiros; Jacobson, Matthew P; Lokey, R Scott.
Afiliação
  • Bockus AT; †Department of Chemistry and Biochemistry, University of California-Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States.
  • Lexa KW; ‡Department of Pharmaceutical Chemistry, University of California- San Francisco, 1700 4th Street, San Francisco, California 94158, United States.
  • Pye CR; †Department of Chemistry and Biochemistry, University of California-Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States.
  • Kalgutkar AS; §Pharmacokinetics and Drug Metabolism, Pfizer Inc., Groton, Connecticut 06340, United States.
  • Gardner JW; †Department of Chemistry and Biochemistry, University of California-Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States.
  • Hund KC; †Department of Chemistry and Biochemistry, University of California-Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States.
  • Hewitt WM; †Department of Chemistry and Biochemistry, University of California-Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States.
  • Schwochert JA; †Department of Chemistry and Biochemistry, University of California-Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States.
  • Glassey E; †Department of Chemistry and Biochemistry, University of California-Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States.
  • Price DA; ∥Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States.
  • Mathiowetz AM; ∥Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States.
  • Liras S; ∥Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States.
  • Jacobson MP; ‡Department of Pharmaceutical Chemistry, University of California- San Francisco, 1700 4th Street, San Francisco, California 94158, United States.
  • Lokey RS; †Department of Chemistry and Biochemistry, University of California-Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States.
J Med Chem ; 58(11): 4581-9, 2015 Jun 11.
Article em En | MEDLINE | ID: mdl-25950816
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article