Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence.

Hicks, Kevin G; Delbecq, Scott P; Sancho-Vaello, Enea; Blanc, Marie-Pierre; Dove, Katja K; Prost, Lynne R; Daley, Margaret E; Zeth, Kornelius; Klevit, Rachel E; Miller, Samuel I

Hicks, Kevin G; Delbecq, Scott P; Sancho-Vaello, Enea; Blanc, Marie-Pierre; Dove, Katja K; Prost, Lynne R; Daley, Margaret E; Zeth, Kornelius; Klevit, Rachel E; Miller, Samuel I.

Afiliação

Hicks KG; Department of Microbiology, University of Washington Medical School, Seattle, United States.
Delbecq SP; Department of Biochemistry, University of Washington Medical School, Seattle, United States.
Sancho-Vaello E; Unidad de Biofisica, Centro Mixto Consejo Superior de Investigaciones Cientificas-Universidad del País Vasco/Euskal Herriko Unibertsitatea (CSIC,UPV/EHU), Leioa, Bizkaia, Spain.
Blanc MP; Department of Microbiology, University of Washington Medical School, Seattle, United States.
Dove KK; Department of Biochemistry, University of Washington Medical School, Seattle, United States.
Prost LR; Department of Biochemistry, University of Wisconsin-Madison, Madison, United States.
Daley ME; Department of Chemistry and Biochemistry, University of San Diego, San Diego, United States.
Zeth K; Department of Biochemistry and Molecular Biology, University of Basque Country, Leioa, Spain.
Klevit RE; Department of Biochemistry, University of Washington Medical School, Seattle, United States.
Miller SI; Department of Microbiology, University of Washington Medical School, Seattle, United States.

Elife ; 4: e06792, 2015 May 23.

Article em En | MEDLINE | ID: mdl-26002083

Assuntos

Proteínas de Bactérias/metabolismo; Cátions Bivalentes/metabolismo; Regulação Bacteriana da Expressão Gênica; Concentração de Íons de Hidrogênio; Salmonella typhimurium/efeitos dos fármacos; Salmonella typhimurium/patogenicidade; Fatores de Virulência/biossíntese; Animais; Proteínas de Bactérias/química; Proteínas de Bactérias/genética; Cristalografia por Raios X; Camundongos; Modelos Moleculares; Proteínas Mutantes/química; Proteínas Mutantes/genética; Proteínas Mutantes/metabolismo; Conformação Proteica/efeitos dos fármacos; Salmonelose Animal/microbiologia; Salmonelose Animal/patologia; Virulência

Palavras-chave

Salmonella; bacterial pathogenesis; biochemistry; infectious disease; innate immunity; intracellular virulence; microbiology; sensor kinase; signal transduction

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google