Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition.

Taylor, Isabella C; Hütt-Cabezas, Marianne; Brandt, William D; Kambhampati, Madhuri; Nazarian, Javad; Chang, Howard T; Warren, Katherine E; Eberhart, Charles G; Raabe, Eric H

Taylor, Isabella C; Hütt-Cabezas, Marianne; Brandt, William D; Kambhampati, Madhuri; Nazarian, Javad; Chang, Howard T; Warren, Katherine E; Eberhart, Charles G; Raabe, Eric H.

Afiliação

Taylor IC; From the Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center (ICT, MH-C, WB, CGE, EHR) and Division of Pediatric Oncology (ICT, EHR), Johns Hopkins University, Bloomberg Children's Hospital, Baltimore, Maryland; Children's National Medical Center and George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (MK, JN); Department of Neurology and Ophthalmology, Michigan State University, East Lansing (HTC); and Sparrow Health System,

J Neuropathol Exp Neurol ; 74(8): 778-90, 2015 Aug.

Article em En | MEDLINE | ID: mdl-26115193

Assuntos

Neoplasias do Tronco Encefálico/patologia; Glioma/patologia; Ponte/patologia; Tolerância a Radiação/fisiologia; Animais; Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Western Blotting; Neoplasias do Tronco Encefálico/metabolismo; Imunofluorescência; Glioma/metabolismo; Humanos; Camundongos; Camundongos Nus; Proteína Proto-Oncogênica N-Myc; Proteínas Nucleares/metabolismo; Proteínas Oncogênicas/metabolismo; Ponte/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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