The prion protein inhibits monocytic cell migration by stimulating ß1 integrin adhesion and uropod formation.

Richardson, Dion D; Tol, Simon; Valle-Encinas, Eider; Pleguezuelos, Cayetano; Bierings, Ruben; Geerts, Dirk; Fernandez-Borja, Mar

Richardson, Dion D; Tol, Simon; Valle-Encinas, Eider; Pleguezuelos, Cayetano; Bierings, Ruben; Geerts, Dirk; Fernandez-Borja, Mar.

Afiliação

Richardson DD; Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066CX, The Netherlands.
Tol S; Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066CX, The Netherlands.
Valle-Encinas E; Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066CX, The Netherlands.
Pleguezuelos C; Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066CX, The Netherlands.
Bierings R; Department of Plasma Proteins, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066CX, The Netherlands.
Geerts D; Department of Pediatric Oncology/Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, The Netherlands.
Fernandez-Borja M; Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam 1066CX, The Netherlands m.fernandez@sanquin.nl.

J Cell Sci ; 128(16): 3018-29, 2015 Aug 15.

Article em En | MEDLINE | ID: mdl-26159734

Assuntos

Adesão Celular/genética; Integrina beta1/genética; Príons/genética; Proteína rhoA de Ligação ao GTP/metabolismo; Actinas; Animais; Movimento Celular/genética; Cofilina 1/genética; Citoesqueleto/genética; Citoesqueleto/metabolismo; Humanos; Integrina beta1/metabolismo; Camundongos; Proteínas dos Microfilamentos; Monócitos/metabolismo; Proteínas Priônicas; Príons/metabolismo; Transdução de Sinais; Proteína rhoA de Ligação ao GTP/genética

Palavras-chave

Adhesion; ERM; Migration; Monocyte; Prion protein; RhoA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article