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Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.
O'Dowd, Hardwin; Shannon, Dean E; Chandupatla, Kishan R; Dixit, Vaishali; Engtrakul, Juntyma J; Ye, Zhengqi; Jones, Steven M; O'Brien, Colleen F; Nicolau, David P; Tessier, Pamela R; Crandon, Jared L; Song, Bin; Macikenas, Dainius; Hanzelka, Brian L; Le Tiran, Arnaud; Bennani, Youssef L; Charifson, Paul S; Grillot, Anne-Laure.
Afiliação
  • O'Dowd H; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
  • Shannon DE; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
  • Chandupatla KR; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
  • Dixit V; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
  • Engtrakul JJ; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
  • Ye Z; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
  • Jones SM; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
  • O'Brien CF; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
  • Nicolau DP; Center for Anti-Infective Research and Development, Hartford Hospital , 80 Seymour Street, Hartford, Connecticut 06102, United States.
  • Tessier PR; Center for Anti-Infective Research and Development, Hartford Hospital , 80 Seymour Street, Hartford, Connecticut 06102, United States.
  • Crandon JL; Center for Anti-Infective Research and Development, Hartford Hospital , 80 Seymour Street, Hartford, Connecticut 06102, United States.
  • Song B; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
  • Macikenas D; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
  • Hanzelka BL; Vertex Pharmaceuticals Incorporated , 2500 Crosspark Road, Bioventures Center, Coralville, Iowa 52241, United States.
  • Le Tiran A; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
  • Bennani YL; Vertex Pharmaceuticals Incorporated , 275 Boulevard Armand Frappier, Laval, QC H7V 4A7, Canada.
  • Charifson PS; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
  • Grillot AL; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
ACS Med Chem Lett ; 6(7): 822-6, 2015 Jul 09.
Article em En | MEDLINE | ID: mdl-26191374
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article