Synthetic peptides mimicking the binding site of human acetylcholinesterase for its inhibitor fasciculin 2.

Kafurke, Uwe; Erijman, Ariel; Aizner, Yonatan; Shifman, Julia M; Eichler, Jutta

Kafurke, Uwe; Erijman, Ariel; Aizner, Yonatan; Shifman, Julia M; Eichler, Jutta.

Afiliação

Kafurke U; Department of Chemistry and Pharmacy, University of Erlangen-Nuremberg, Schuhstr. 19, 91052, Erlangen, Germany.
Erijman A; Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
Aizner Y; Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
Shifman JM; Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
Eichler J; Department of Chemistry and Pharmacy, University of Erlangen-Nuremberg, Schuhstr. 19, 91052, Erlangen, Germany.

J Pept Sci ; 21(9): 723-30, 2015 Sep.

Article em En | MEDLINE | ID: mdl-26200472

Assuntos

Acetilcolinesterase/química; Acetilcolinesterase/metabolismo; Venenos Elapídicos/química; Venenos Elapídicos/metabolismo; Peptídeos/química; Peptídeos/síntese química; Sítios de Ligação; Humanos

Palavras-chave

acetylcholinesterase; binding site mimic; computational design; fasciculin 2; protein-protein interactions; solid-phase synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article