Heterocyclization Approach for Electrooxidative Coupling of Functional Primary Alkylamines with Aromatics.
J Am Chem Soc
; 137(31): 9816-9, 2015 Aug 12.
Article
em En
| MEDLINE
| ID: mdl-26225441
ABSTRACT
A new approach for electrooxidative coupling of aromatic compounds and primary alkylamines bearing a functional group such as a hydroxyl group and an amino group was developed. The key to the success of the transformation is heterocyclization of functional primary alkylamines. Treatment of primary alkylamines bearing a functional group with nitriles or their equivalents gives the corresponding heterocycles. The electrochemical oxidation of aromatic substrates in the presence of the heterocycles followed by chemical reaction under nonoxidative conditions gave the desired coupling products.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article