Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT.

Vaughn, Lauren S; Bragg, D Cristopher; Sharma, Nutan; Camargos, Sarah; Cardoso, Francisco; Patel, Rekha C

Vaughn, Lauren S; Bragg, D Cristopher; Sharma, Nutan; Camargos, Sarah; Cardoso, Francisco; Patel, Rekha C.

Afiliação

Vaughn LS; From the University of South Carolina, Department of Biological Sciences, Columbia, South Carolina 29208.
Bragg DC; Massachusetts General Hospital, Department of Neurology, Charlestown, Massachusetts 02129, and.
Sharma N; Massachusetts General Hospital, Department of Neurology, Charlestown, Massachusetts 02129, and.
Camargos S; Federal University of Minas Gerais, Department of Internal Medicine, 31270-901 Belo Horizonte, MG, Brazil.
Cardoso F; Federal University of Minas Gerais, Department of Internal Medicine, 31270-901 Belo Horizonte, MG, Brazil.
Patel RC; From the University of South Carolina, Department of Biological Sciences, Columbia, South Carolina 29208, patelr@biol.sc.edu.

J Biol Chem ; 290(37): 22543-57, 2015 Sep 11.

Article em En | MEDLINE | ID: mdl-26231208

Assuntos

Apoptose; Distonia; Mutação de Sentido Incorreto; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo; eIF-2 Quinase/metabolismo; Substituição de Aminoácidos; Distonia/genética; Distonia/metabolismo; Distonia/patologia; Feminino; Células HeLa; Humanos; Masculino; eIF-2 Quinase/genética

Palavras-chave

apoptosis; cell death; endoplasmic reticulum stress (ER stress); interferon; protein kinase RNA-activated (PKR)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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