Insulin growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity through IGF-1 receptor-mediated mechanisms in the epileptic brain.

Jiang, Guohui; Wang, Wei; Cao, Qingqing; Gu, Juan; Mi, Xiujuan; Wang, Kewei; Chen, Guojun; Wang, Xuefeng

Jiang, Guohui; Wang, Wei; Cao, Qingqing; Gu, Juan; Mi, Xiujuan; Wang, Kewei; Chen, Guojun; Wang, Xuefeng.

Afiliação

Jiang G; Department of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, China Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Wang W; Department of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, China.
Cao Q; Department of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, China.
Gu J; Department of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, China.
Mi X; Department of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, China.
Wang K; Department of Pharmacology, Peking University School of Medicine, Beijing, China.
Chen G; Department of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, China.
Wang X; Department of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, China xfyp@163.com woodchen2015@163.com.

Clin Sci (Lond) ; 129(12): 1047-60, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26286172

Assuntos

Ondas Encefálicas; Epilepsia do Lobo Temporal/metabolismo; Hipocampo/metabolismo; Fator de Crescimento Insulin-Like I/metabolismo; Receptores de Somatomedina/metabolismo; Adolescente; Adulto; Animais; Anticonvulsivantes/farmacologia; Estudos de Casos e Controles; Modelos Animais de Doenças; Eletroencefalografia; Ativação Enzimática; Epilepsia do Lobo Temporal/induzido quimicamente; Epilepsia do Lobo Temporal/fisiopatologia; Epilepsia do Lobo Temporal/prevenção & controle; Potenciais Pós-Sinápticos Excitadores; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Feminino; Hipocampo/efeitos dos fármacos; Hipocampo/fisiopatologia; Humanos; Fator de Crescimento Insulin-Like I/farmacologia; Masculino; Pessoa de Meia-Idade; Pentilenotetrazol; Fosforilação; Pilocarpina; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ratos Sprague-Dawley; Receptor IGF Tipo 1; Receptores de Somatomedina/antagonistas & inibidores; Transdução de Sinais; Fatores de Tempo; Regulação para Cima; Adulto Jovem

Palavras-chave

Akt; ERK1/2; epilepsy seizures; insulin-like growth factor-1; insulin-like growth factor-1 receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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