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Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.
Nepovimova, Eugenie; Korabecny, Jan; Dolezal, Rafael; Babkova, Katerina; Ondrejicek, Ales; Jun, Daniel; Sepsova, Vendula; Horova, Anna; Hrabinova, Martina; Soukup, Ondrej; Bukum, Neslihan; Jost, Petr; Muckova, Lubica; Kassa, Jiri; Malinak, David; Andrs, Martin; Kuca, Kamil.
Afiliação
  • Nepovimova E; Biomedical Research Centre, University Hospital Hradec Kralove , Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
  • Korabecny J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence , Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
  • Dolezal R; Department of Intensive Medicine and Forensic Studies; Department of Physiology and Pathophysiology, Faculty of Medicine, University of Ostrava , Syllabova 19, 703 00 Ostrava, Czech Republic.
  • Babkova K; Biomedical Research Centre, University Hospital Hradec Kralove , Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
  • Ondrejicek A; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence , Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
  • Jun D; National Institute of Mental Health , Topolova 748, 250 67 Klecany, Czech Republic.
  • Sepsova V; Biomedical Research Centre, University Hospital Hradec Kralove , Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
  • Horova A; Biomedical Research Centre, University Hospital Hradec Kralove , Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
  • Hrabinova M; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence , Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
  • Soukup O; Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague , Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
  • Bukum N; Biomedical Research Centre, University Hospital Hradec Kralove , Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
  • Jost P; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence , Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
  • Muckova L; Biomedical Research Centre, University Hospital Hradec Kralove , Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
  • Kassa J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence , Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
  • Malinak D; Biomedical Research Centre, University Hospital Hradec Kralove , Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
  • Andrs M; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence , Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
  • Kuca K; Biomedical Research Centre, University Hospital Hradec Kralove , Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
J Med Chem ; 58(22): 8985-9003, 2015 Nov 25.
Article em En | MEDLINE | ID: mdl-26503905
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article