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Stable Evans Blue Derived Exendin-4 Peptide for Type 2 Diabetes Treatment.
Liu, Yi; Wang, Guohao; Zhang, Huimin; Ma, Ying; Lang, Lixin; Jacobson, Orit; Kiesewetter, Dale O; Zhu, Lei; Gao, Shi; Ma, Qingjie; Chen, Xiaoyuan.
Afiliação
  • Liu Y; China-Japan Union Hospital of Jilin University , Changchun, Jilin 130033, China.
  • Wang G; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineer-ing (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Zhang H; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University , Xiamen, 361102, China.
  • Ma Y; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineer-ing (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Lang L; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineer-ing (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Jacobson O; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineer-ing (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Kiesewetter DO; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineer-ing (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Zhu L; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineer-ing (NIBIB), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
  • Gao S; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University , Xiamen, 361102, China.
  • Ma Q; China-Japan Union Hospital of Jilin University , Changchun, Jilin 130033, China.
  • Chen X; China-Japan Union Hospital of Jilin University , Changchun, Jilin 130033, China.
Bioconjug Chem ; 27(1): 54-8, 2016 Jan 20.
Article em En | MEDLINE | ID: mdl-26641886
ABSTRACT
In the treatment of type 2 diabetes mellitus, it is very important to develop therapeutics with prolonged circulation half-life. Exendin-4 is a glucagon like peptide-1 receptor (GLP-1R) agonist that has been modified in different ways for imaging insulinoma and for treating type-2 diabetes. In this work, we synthesized a maleimide derivative of truncated Evans blue dye (MEB-C3-Mal) to conjugate with (Cys(40))exendin-4 to obtain a highly stable MEB-C3-(Cys(40))exendin-4 (denoted as Abextide II). Through in situ binding with endogenous albumin, Abextide II lowers blood glucose level and prolongs the hypoglycemic effect in a type 2 diabetes mouse model more than the FDA approved Albiglutide.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article