Hybrid Pyrrole-Imidazole Alkaloids from the Sponge Agelas sceptrum.
J Nat Prod
; 79(2): 434-7, 2016 Feb 26.
Article
em En
| MEDLINE
| ID: mdl-26872204
ABSTRACT
A chemical investigation of the tropical sponge Agelas sceptrum from Plana Cays (Bahamas) led to the isolation of two hybrid pyrrole-imidazole alkaloids (PIAs), 15'-oxoadenosceptrin (1) and decarboxyagelamadin C (2). Herein, we report their challenging structure elucidation established by NMR and ECD spectroscopy. 15'-Oxoadenosceptrin (1) shows sceptrin merged with an adenine moiety, not yet encountered in the PIA family, whereas decarboxyagelamadin C (2) is a close derivative of agelamadins C to E recently isolated from an Agelas sp. from Okinawa.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Animals
País/Região como assunto:
Bahamas
/
Caribe ingles
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article