Your browser doesn't support javascript.
loading
KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects.
Huskey, Su-Er W; Zhu, Chun-qi; Fredenhagen, Andreas; Kühnöl, Jürgen; Luneau, Alexandre; Jian, Zhigang; Yang, Ziping; Miao, Zhuang; Yang, Fan; Jain, Jay P; Sunkara, Gangadhar; Mangold, James B; Stein, Daniel S.
Afiliação
  • Huskey SE; Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.) su.huskey@novartis.com.
  • Zhu CQ; Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.).
  • Fredenhagen A; Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.).
  • Kühnöl J; Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.).
  • Luneau A; Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.).
  • Jian Z; Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.).
  • Yang Z; Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.).
  • Miao Z; Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.).
  • Yang F; Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.).
  • Jain JP; Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.).
  • Sunkara G; Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.).
  • Mangold JB; Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.).
  • Stein DS; Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.).
Drug Metab Dispos ; 44(5): 672-82, 2016 May.
Article em En | MEDLINE | ID: mdl-26921387
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adult / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adult / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article