A Single Intrathecal or Intraperitoneal Injection of CB2 Receptor Agonist Attenuates Bone Cancer Pain and Induces a Time-Dependent Modification of GRK2.

Lu, Cui'e; Shi, Linyu; Sun, Bei; Zhang, Yu; Hou, Bailing; Sun, Yu'e; Ma, Zhengliang; Gu, Xiaoping

Lu, Cui'e; Shi, Linyu; Sun, Bei; Zhang, Yu; Hou, Bailing; Sun, Yu'e; Ma, Zhengliang; Gu, Xiaoping.

Afiliação

Lu C; Department of Anesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, 210008, Jiangsu, China.
Shi L; Department of Anesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, 210008, Jiangsu, China.
Sun B; Department of Anesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, 210008, Jiangsu, China.
Zhang Y; Department of Anesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, 210008, Jiangsu, China.
Hou B; Department of Anesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, 210008, Jiangsu, China.
Sun Y; Department of Anesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, 210008, Jiangsu, China.
Ma Z; Department of Anesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, 210008, Jiangsu, China. mazhengliang1964@nju.edu.cn.
Gu X; Department of Anesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, 210008, Jiangsu, China. 13813996903@126.com.

Cell Mol Neurobiol ; 37(1): 101-109, 2017 Jan.

Article em En | MEDLINE | ID: mdl-26935064

Assuntos

Neoplasias Ósseas/metabolismo; Dor do Câncer/metabolismo; Quinase 2 de Receptor Acoplado a Proteína G/biossíntese; Indóis/administração & dosagem; Receptor CB2 de Canabinoide/agonistas; Receptor CB2 de Canabinoide/metabolismo; Animais; Neoplasias Ósseas/tratamento farmacológico; Dor do Câncer/tratamento farmacológico; Linhagem Celular Tumoral; Feminino; Injeções Intraperitoneais; Injeções Espinhais; Medição da Dor/efeitos dos fármacos; Medição da Dor/métodos; Distribuição Aleatória; Ratos; Ratos Sprague-Dawley; Fatores de Tempo

Palavras-chave

Bone cancer pain; CB2; GRK2; JWH-015; Spinal cord

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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