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Rhubarb Anthraquinones Protect Rats against Mercuric Chloride (HgCl2)-Induced Acute Renal Failure.
Gao, Dan; Zeng, Ling-Na; Zhang, Pin; Ma, Zhi-Jie; Li, Rui-Sheng; Zhao, Yan-Ling; Zhang, Ya-Ming; Guo, Yu-Min; Niu, Ming; Bai, Zhao-Fang; Xiao, Xiao-He; Gao, Wei-Wei; Wang, Jia-Bo.
Afiliação
  • Gao D; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100094, China. gaodan_gd@163.com.
  • Zeng LN; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China. gaodan_gd@163.com.
  • Zhang P; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China. zeng_lingna85@126.com.
  • Ma ZJ; Integrative Medicine Center, 302 Military Hospital, Beijing 100039, China. zhang_ping77@126.com.
  • Li RS; Beijing Friendship Hospital Attached of Capital Medical University, Beijing 100050, China. mazhij_123@126.com.
  • Zhao YL; Experimental Animal Center, 302 Military Hospital, Beijing 100039, China. ruisheng_sci@126.com.
  • Zhang YM; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China. zhaoyl_123@126.com.
  • Guo YM; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China. zymprchina@126.com.
  • Niu M; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China. guoyuming_123@126.com.
  • Bai ZF; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China. niumingbright@126.com.
  • Xiao XH; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China. bai_zf001@126.com.
  • Gao WW; Integrative Medicine Center, 302 Military Hospital, Beijing 100039, China. pharmacy302xxh@126.com.
  • Wang JB; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100094, China. wwgao411@sina.com.
Molecules ; 21(3): 298, 2016 Mar 08.
Article em En | MEDLINE | ID: mdl-27005597
ABSTRACT
Mercury (Hg) causes severe nephrotoxicity in subjects with excess exposure. This work attempted to identify whether a natural medicine--rhubarb--has protective effects against mercuric chloride (HgCl2)-induced acute renal failure (ARF), and which of its components contributed most to the treatment. Total rhubarb extract (TR) were separated to the total anthraquinones (TA), the total tannins (TT) and remaining component extract (RC). Each extract was orally pre-administered to rats for five successive days followed by HgCl2 injection to induce kidney injury. Subsequently, renal histopathology and biochemical examinations were performed in vitro to evaluate the protective effects. Pharmacological studies showed that TR and TA, but not TT or RC manifested significant protection activity against HgCl2-induced ARF. There were also significant declines of serum creatine, urea nitrogen values and increases of total protein albumin levels in TR and TA treated groups compared to HgCl2 alone (p < 0.05). At last, the major components in TA extract were further identified as anthraquinones by liquid chromatography coupled mass spectroscopy. This study thus provides observational evidences that rhubarb could ameliorate HgCl2-induced ARF and its anthraquinones in particular are the effective components responsible for this activity in rhubarb extract.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article