[The shades of anti-Jo1 positive antisynthetase syndrome in a Hungarian cohort]. / Az anti-Jo-1-pozitív antiszintetáz szindróma jellegzetességei gondozott betegeink alapján.
Orv Hetil
; 157(15): 575-83, 2016 Apr 10.
Article
em Hu
| MEDLINE
| ID: mdl-27039996
ABSTRACT
INTRODUCTION:
In idiopathic inflammatory myopathies, the presence of anti-Jo-1 antibody defines a distinct clinical phenotype (myositis, arthritis, interstitial lung disease, Raynaud's phenomenon fever, mechanic's hands), called antisynthetase syndrome.AIM:
To determine the demographic data as well as clinical, laboratory and terapeutical features of anti-Jo1 positive patients, followed by the department of the authors.METHOD:
The medical records of 49 consecutive anti-Jo1 patients were reviewed.RESULTS:
Demographic and clinical results were very similar to those published by other centers. Significant correlation was found between the anti-Jo-1 titer and the creatine kinase and C-reactive protein levels. Distinct laboratory results measured at the time of diagnosis of the disease (C-reactive protein, antigen A associated with Sjogren's syndrome, positive rheumatoid factor), and the presence of certain clinical symptoms (fever, vasculitic skin) may indicate a worse prognosis within the antisyntetase positive patient group.CONCLUSION:
In the cases above more agressive immunosuppressive therapy may be required.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
Hu
Ano de publicação:
2016
Tipo de documento:
Article