First metabolic profile of PV8, a novel synthetic cathinone, in human hepatocytes and urine by high-resolution mass spectrometry.

Swortwood, Madeleine J; Ellefsen, Kayla N; Wohlfarth, Ariane; Diao, Xingxing; Concheiro-Guisan, Marta; Kronstrand, Robert; Huestis, Marilyn A

Swortwood, Madeleine J; Ellefsen, Kayla N; Wohlfarth, Ariane; Diao, Xingxing; Concheiro-Guisan, Marta; Kronstrand, Robert; Huestis, Marilyn A.

Afiliação

Swortwood MJ; Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd. Suite 05A721, Baltimore, MD, 21224, USA.
Ellefsen KN; Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd. Suite 05A721, Baltimore, MD, 21224, USA.
Wohlfarth A; Program in Toxicology, University of Maryland Baltimore, Baltimore, MD, 21201, USA.
Diao X; Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd. Suite 05A721, Baltimore, MD, 21224, USA.
Concheiro-Guisan M; Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, 58758, Linköping, Sweden.
Kronstrand R; Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, 58185, Linköping, Sweden.
Huestis MA; Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd. Suite 05A721, Baltimore, MD, 21224, USA.

Anal Bioanal Chem ; 408(18): 4845-56, 2016 Jul.

Article em En | MEDLINE | ID: mdl-27185540

Assuntos

Alcaloides/análise; Alcaloides/metabolismo; Perfilação da Expressão Gênica/métodos; Hepatócitos/metabolismo; Espectrometria de Massas/métodos; Psicotrópicos/metabolismo; Detecção do Abuso de Substâncias/métodos; Células Cultivadas; Humanos; Metaboloma/fisiologia; Psicotrópicos/análise; Reprodutibilidade dos Testes; Sensibilidade e Especificidade; Urinálise/métodos

Palavras-chave

HRMS; Hepatocytes; Metabolic profiling; Novel psychoactive substances; PV8; Synthetic cathinones

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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