Bone marrow lesions and synovitis on MRI associate with radiographic progression after 2â
years in hand osteoarthritis.
Ann Rheum Dis
; 76(1): 214-217, 2017 Jan.
Article
em En
| MEDLINE
| ID: mdl-27323771
ABSTRACT
OBJECTIVE:
To study the association of magnetic resonance (MR) features with radiographic progression of hand osteoarthritis over 2â years.METHODS:
Of 87 primary patients with hand osteoarthritis (82% women, mean age 59â years), baseline distal and proximal interphalangeal joint contrast-enhanced MR images were scored 0-3 for bone marrow lesions (BMLs) and synovitis following the Oslo score. Baseline and 2-year follow-up radiographs were scored following Kellgren-Lawrence (KL) (0-4) and OsteoArthritis Research Society International (OARSI) scoring methods (0-3 osteophytes, joint space narrowing (JSN)). Increase ≥1 defined progression. Associations between MR features and radiographic progression were explored on joint and on patient level, adjusting for age, sex, body mass index, synovitis and BML. Joints in end-stage were excluded.RESULTS:
Of 696 analysed joints, 324 had baseline KL=0, 28 KL=4 and after 2â years 78 joints progressed. BML grade 2/3 was associated with KL progression (2/3 vs 0 adjusted risk ratio (RR) (95% CI) 3.3 (2.1 to 5.3)) and with osteophyte or JSN progression, as was synovitis. Summated scores were associated with radiographic progression on patient level (RR crude BML 1.08 (1.01 to 1.2), synovitis 1.09 (1.04 to 1.1), adjusted synovitis 1.08 (1.03 to 1.1)).CONCLUSIONS:
BMLs, next to synovitis, show, already after 2â years, graded associations with radiographic progression, suggesting that both joint tissues could be important targets for therapy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article