DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.

Rau, Rachel E; Rodriguez, Benjamin A; Luo, Min; Jeong, Mira; Rosen, Allison; Rogers, Jason H; Campbell, Carly T; Daigle, Scott R; Deng, Lishing; Song, Yongcheng; Sweet, Steve; Chevassut, Timothy; Andreeff, Michael; Kornblau, Steven M; Li, Wei; Goodell, Margaret A

Rau, Rachel E; Rodriguez, Benjamin A; Luo, Min; Jeong, Mira; Rosen, Allison; Rogers, Jason H; Campbell, Carly T; Daigle, Scott R; Deng, Lishing; Song, Yongcheng; Sweet, Steve; Chevassut, Timothy; Andreeff, Michael; Kornblau, Steven M; Li, Wei; Goodell, Margaret A.

Afiliação

Rau RE; Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX; Dan L. Duncan Cancer Center.
Rodriguez BA; Dan L. Duncan Cancer Center, Department of Molecular and Cellular Biology.
Luo M; Department of Molecular and Human Genetics, Stem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX;
Jeong M; Department of Molecular and Human Genetics, Stem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX;
Rosen A; Department of Molecular and Human Genetics, Stem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX;
Rogers JH; Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX;
Campbell CT; Epizyme, Inc., Cambridge, MA;
Daigle SR; Epizyme, Inc., Cambridge, MA;
Deng L; Department of Pharmacology, Baylor College of Medicine, Houston, TX;
Song Y; Department of Pharmacology, Baylor College of Medicine, Houston, TX;
Sweet S; Genome Damage and Stability Centre, and.
Chevassut T; Department of Haematology, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom; and.
Andreeff M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Kornblau SM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Li W; Dan L. Duncan Cancer Center, Department of Molecular and Cellular Biology.
Goodell MA; Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX; Dan L. Duncan Cancer Center, Department of Molecular and Human Genetics, Stem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX;

Blood ; 128(7): 971-81, 2016 08 18.

Article em En | MEDLINE | ID: mdl-27335278

Assuntos

DNA (Citosina-5-)-Metiltransferases/genética; Leucemia Mieloide Aguda/tratamento farmacológico; Leucemia Mieloide Aguda/enzimologia; Metiltransferases/genética; Metiltransferases/metabolismo; Terapia de Alvo Molecular; Mutação/genética; Adenosina/análogos & derivados; Adenosina/farmacologia; Adenosina/uso terapêutico; Animais; Apoptose; Pontos de Checagem do Ciclo Celular; Diferenciação Celular; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; DNA Metiltransferase 3A; Regulação Leucêmica da Expressão Gênica/efeitos dos fármacos; Células-Tronco Hematopoéticas/efeitos dos fármacos; Células-Tronco Hematopoéticas/metabolismo; Histona-Lisina N-Metiltransferase; Histonas/metabolismo; Humanos; Leucemia Mieloide Aguda/genética; Leucemia Mieloide Aguda/patologia; Lisina/metabolismo; Metilação; Camundongos Endogâmicos C57BL; Compostos de Fenilureia/farmacologia; Compostos de Fenilureia/uso terapêutico; Ratos; Fatores de Tempo; Ensaio Tumoral de Célula-Tronco; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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